The FlexChem Peptide Synthesis System provides a simple technique for performing parallel, manual synthesis of 96 or 48 peptides. The core of the system is a chemically resistant
reactor / filtration block with independently removable sealing covers. Peripheral devices for loading solid supports; vacuum washing and recovery of products; and an optional benchtop rotator complete the system.

96 and 48 Well Reactor Blocks for Varying Scale Synthesis
Peptide synthesis chemistries are performed in heavy-duty, polypropylene multi-well blocks containing a polyethylene frit inserted into the bottom of each well. This design prevents cross contamination between wells during incubation. Two reactor block formats and well volumes are available. Both block formats can be used with the same sealing hardware.

• The 96 well model has standard microplate well spacing with a
  well volume of 2.4 ml.
• The 48 well model has a well volume of 5.6 ml for larger reactions.

Benchtop Rotator for Efficient Mixing and Superior Coupling Efficiencies
End-over-end agitation of sealed reactors during each synthetic step provides higher coupling efficiencies compared to rocking or reciprocating movement. The FlexChem Model 202 Ambient Rotator, designed for chemistry applications, gently and safely rotates up to four sealed FlexChem reactor block assemblies. An optional General Purpose rotator provides ambient mixing of everyday chemistry vessels.

Manifolds for Washing Supports and Collecting Cleavage Products
Vacuum manifolds are available for washing supports between couplings and collecting final products into a collection plate. The sealing system is uniquely designed to use independently
removable gasketed covers that allow the bottom cover to be removed for insertion of the reactor block into the manifolds.

"Trap Door" Loader Simplifies Handling Supports
Easy-to-use Trap Door Loaders deliver defined amounts of solid support to each well of the reactor block in a single step. Supports are first spread across the surface of the loader to deliver a specific amount of resin (25, 50, 75 or 100 mg of dry silica) into the loader wells.
The material is then transferred to the block by sliding a "trap door", allowing the resin to fill all block wells simultaneously.